Profound autism
Recent articles
Reporter’s notebook: Highlights from INSAR 2026
At the 25th annual meeting of the International Society for Autism Research, scientists, clinicians and self-advocates gathered to discuss topics such as autism genetics and the gap between clinical trials and real-world benefits.
Reporter’s notebook: Highlights from INSAR 2026
At the 25th annual meeting of the International Society for Autism Research, scientists, clinicians and self-advocates gathered to discuss topics such as autism genetics and the gap between clinical trials and real-world benefits.
Expediting clinical trials for profound autism: Q&A with Matthew State
Aligning Research to Impact Autism, a new initiative funded by the Sergey Brin Family Foundation, wants to bring basic science discoveries to the clinic faster.
Expediting clinical trials for profound autism: Q&A with Matthew State
Aligning Research to Impact Autism, a new initiative funded by the Sergey Brin Family Foundation, wants to bring basic science discoveries to the clinic faster.
Brain organoid size matches intensity of social problems in autistic people
Overgrown organoids could point to mechanisms underlying profound autism.
Brain organoid size matches intensity of social problems in autistic people
Overgrown organoids could point to mechanisms underlying profound autism.
Pinning down ‘profound autism’ for reliable research: Q&A with Matthew Siegel
A clear and actionable definition for the term could enhance research and improve care, Matthew Siegel says.
Pinning down ‘profound autism’ for reliable research: Q&A with Matthew Siegel
A clear and actionable definition for the term could enhance research and improve care, Matthew Siegel says.
Building bridges: Collaboration across the autism community
An autistic person and the mother of an autistic child explore partnership in the autism community.
Building bridges: Collaboration across the autism community
An autistic person and the mother of an autistic child explore partnership in the autism community.
Weaponized heterogeneity only harms the most vulnerable autistic people
Focusing on aspects of autistic experience that we all share may lead more quickly to our shared goal of improved outcomes for all autistic people.
Weaponized heterogeneity only harms the most vulnerable autistic people
Focusing on aspects of autistic experience that we all share may lead more quickly to our shared goal of improved outcomes for all autistic people.
It’s time to embrace ‘profound autism’
My experience at the Autism-Europe International Congress — and as a parent of a child with profound autism — makes me more convinced than ever that we need to bifurcate the diagnosis of ‘autism spectrum disorder’ and add a new diagnosis of ‘profound autism’ to better serve this vulnerable population.
It’s time to embrace ‘profound autism’
My experience at the Autism-Europe International Congress — and as a parent of a child with profound autism — makes me more convinced than ever that we need to bifurcate the diagnosis of ‘autism spectrum disorder’ and add a new diagnosis of ‘profound autism’ to better serve this vulnerable population.
New program offers $35K grants to study ‘profound autism’
People who have ‘profound autism’ — those with severe intellectual disability, limited communication abilities or both — tend to be excluded from research. The Autism Science Foundation seeks to change that.
New program offers $35K grants to study ‘profound autism’
People who have ‘profound autism’ — those with severe intellectual disability, limited communication abilities or both — tend to be excluded from research. The Autism Science Foundation seeks to change that.
Mapping the futures of autistic children
Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?
Mapping the futures of autistic children
Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?
Big brain may mark subtype of autism
Autistic boys with large brains in early childhood still have large brains in adolescence, challenging the long-standing idea that brain enlargement in autism is temporary.
Big brain may mark subtype of autism
Autistic boys with large brains in early childhood still have large brains in adolescence, challenging the long-standing idea that brain enlargement in autism is temporary.
Explore more from The Transmitter
Every neuroscience lab needs an ethicist
The ethics issues that arise in neuroscience research are usually novel, unresolved and understudied. Embedding ethicists in labs helps scientists navigate these challenges and develop strategies in real time to prevent harm.
Every neuroscience lab needs an ethicist
The ethics issues that arise in neuroscience research are usually novel, unresolved and understudied. Embedding ethicists in labs helps scientists navigate these challenges and develop strategies in real time to prevent harm.
Beyond glucose: The brain may feed itself
Myelin may serve as an energy reserve for the brain, according to recent findings, prompting neuroscientists to rethink how the brain stores, shares and protects energy.
Beyond glucose: The brain may feed itself
Myelin may serve as an energy reserve for the brain, according to recent findings, prompting neuroscientists to rethink how the brain stores, shares and protects energy.
SHANK3-variant effects in primates, and more
Here is a roundup of autism-related news and research spotted around the web for the week of 25 May.
SHANK3-variant effects in primates, and more
Here is a roundup of autism-related news and research spotted around the web for the week of 25 May.