Profound autism

Recent articles

Research image of autism-linked gene PTEN changes in neurons.

A consensus on the definition of profound autism, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 5 July.

By Sarah Thau
7 July 2026 | 2 min read
Conference attendees.

Reporter’s notebook: Highlights from INSAR 2026

At the 25th annual meeting of the International Society for Autism Research, scientists, clinicians and self-advocates gathered to discuss topics such as autism genetics and the gap between clinical trials and real-world benefits.

By Diana Kwon
30 April 2026 | 6 min read
A clinician holds a clipboard while someone else sits on a couch.

Expediting clinical trials for profound autism: Q&A with Matthew State

Aligning Research to Impact Autism, a new initiative funded by the Sergey Brin Family Foundation, wants to bring basic science discoveries to the clinic faster.

By Lauren Schenkman
24 April 2025 | 8 min read
Black-and-white research image of brain organoids.

Brain organoid size matches intensity of social problems in autistic people

Overgrown organoids could point to mechanisms underlying profound autism.

By Holly Barker
18 July 2024 | 5 min read
Portrait of Matthew Siegel sitting on a staircase.

Pinning down ‘profound autism’ for reliable research: Q&A with Matthew Siegel

A clear and actionable definition for the term could enhance research and improve care, Matthew Siegel says.

By Katie Moisse
13 June 2024 | 7 min read

Building bridges: Collaboration across the autism community

An autistic person and the mother of an autistic child explore partnership in the autism community.

By Samantha Easter, Amy S.F. Lutz
24 October 2023 | 10 min read
Photograph of a woman in a dim room looking out her window.

Weaponized heterogeneity only harms the most vulnerable autistic people

Focusing on aspects of autistic experience that we all share may lead more quickly to our shared goal of improved outcomes for all autistic people.

By Mary Doherty
17 April 2023 | 8 min read
Lone figure treads a central path that splits into two, surrounded on both sides by an uncertain, shifting landscape in murky colors.

It’s time to embrace ‘profound autism’

My experience at the Autism-Europe International Congress — and as a parent of a child with profound autism — makes me more convinced than ever that we need to bifurcate the diagnosis of ‘autism spectrum disorder’ and add a new diagnosis of ‘profound autism’ to better serve this vulnerable population.

By Alison Singer
27 October 2022 | 8 min read
An abstract "funding mechanism" featuring dollar bills alongside tubes, beakers and wires

New program offers $35K grants to study ‘profound autism’

People who have ‘profound autism’ — those with severe intellectual disability, limited communication abilities or both — tend to be excluded from research. The Autism Science Foundation seeks to change that.

By Peter Hess
18 July 2022 | 5 min read
Illustration shows yellow landscape with blue sections and a lot of trains on paths with kids on the trains, going different directions.

Mapping the futures of autistic children

Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?

By Elizabeth Svoboda
14 July 2021 | 18 min read

Explore more from The Transmitter

Textbook model of hippocampus’s role in memory may need updating

The CA3 region, long thought to have just one circuit, has two, sporting different wiring and functions, a new preprint suggests.

By Alissa de Chassey
4 August 2026 | 5 min read
Single-cell spatial transcriptomics chart maps of cell types.

Using antisense oligos to plumb rare genetic conditions, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 3 August.

By Jill Adams
4 August 2026 | 2 min read
Ilustração de canto de pássaro, cérebro de pássaro e DNA.

Este artigo mudou minha vida: adotando um dos primeiros modelos de neurociência naturalística

Um artigo publicado na PNAS em 1992 mostrou que o canto das aves aumenta a expressão de um gene de resposta imediata no prosencéfalo dessas aves. O estudo revelou a Ribeiro a importância de investigar as respostas moleculares em contextos naturalísticos.

By Sidarta Ribeiro
3 August 2026 | 5 min read