Profound autism
Recent articles
Reporter’s notebook: Highlights from INSAR 2026
At the 25th annual meeting of the International Society for Autism Research, scientists, clinicians and self-advocates gathered to discuss topics such as autism genetics and the gap between clinical trials and real-world benefits.
Reporter’s notebook: Highlights from INSAR 2026
At the 25th annual meeting of the International Society for Autism Research, scientists, clinicians and self-advocates gathered to discuss topics such as autism genetics and the gap between clinical trials and real-world benefits.
Expediting clinical trials for profound autism: Q&A with Matthew State
Aligning Research to Impact Autism, a new initiative funded by the Sergey Brin Family Foundation, wants to bring basic science discoveries to the clinic faster.
Expediting clinical trials for profound autism: Q&A with Matthew State
Aligning Research to Impact Autism, a new initiative funded by the Sergey Brin Family Foundation, wants to bring basic science discoveries to the clinic faster.
Brain organoid size matches intensity of social problems in autistic people
Overgrown organoids could point to mechanisms underlying profound autism.
Brain organoid size matches intensity of social problems in autistic people
Overgrown organoids could point to mechanisms underlying profound autism.
Pinning down ‘profound autism’ for reliable research: Q&A with Matthew Siegel
A clear and actionable definition for the term could enhance research and improve care, Matthew Siegel says.
Pinning down ‘profound autism’ for reliable research: Q&A with Matthew Siegel
A clear and actionable definition for the term could enhance research and improve care, Matthew Siegel says.
Building bridges: Collaboration across the autism community
An autistic person and the mother of an autistic child explore partnership in the autism community.
Building bridges: Collaboration across the autism community
An autistic person and the mother of an autistic child explore partnership in the autism community.
Weaponized heterogeneity only harms the most vulnerable autistic people
Focusing on aspects of autistic experience that we all share may lead more quickly to our shared goal of improved outcomes for all autistic people.
Weaponized heterogeneity only harms the most vulnerable autistic people
Focusing on aspects of autistic experience that we all share may lead more quickly to our shared goal of improved outcomes for all autistic people.
It’s time to embrace ‘profound autism’
My experience at the Autism-Europe International Congress — and as a parent of a child with profound autism — makes me more convinced than ever that we need to bifurcate the diagnosis of ‘autism spectrum disorder’ and add a new diagnosis of ‘profound autism’ to better serve this vulnerable population.
It’s time to embrace ‘profound autism’
My experience at the Autism-Europe International Congress — and as a parent of a child with profound autism — makes me more convinced than ever that we need to bifurcate the diagnosis of ‘autism spectrum disorder’ and add a new diagnosis of ‘profound autism’ to better serve this vulnerable population.
New program offers $35K grants to study ‘profound autism’
People who have ‘profound autism’ — those with severe intellectual disability, limited communication abilities or both — tend to be excluded from research. The Autism Science Foundation seeks to change that.
New program offers $35K grants to study ‘profound autism’
People who have ‘profound autism’ — those with severe intellectual disability, limited communication abilities or both — tend to be excluded from research. The Autism Science Foundation seeks to change that.
Mapping the futures of autistic children
Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?
Mapping the futures of autistic children
Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?
Big brain may mark subtype of autism
Autistic boys with large brains in early childhood still have large brains in adolescence, challenging the long-standing idea that brain enlargement in autism is temporary.
Big brain may mark subtype of autism
Autistic boys with large brains in early childhood still have large brains in adolescence, challenging the long-standing idea that brain enlargement in autism is temporary.
Explore more from The Transmitter
Long-sought walking circuit found in fruit flies
The neuronal circuit controlling repetitive locomotion patterns in any animal has been a mystery until now.
Long-sought walking circuit found in fruit flies
The neuronal circuit controlling repetitive locomotion patterns in any animal has been a mystery until now.
Crisis de financiación en Argentina desata nueva ola de protestas
Dos años luego de que colapsara la financiación para investigación del país colapsara, los científicos están manifestando en contra del incumplimiento del gobierno para restaurar becas cortadas previamente y aumentar salarios como lo establece una del 2025.
Crisis de financiación en Argentina desata nueva ola de protestas
Dos años luego de que colapsara la financiación para investigación del país colapsara, los científicos están manifestando en contra del incumplimiento del gobierno para restaurar becas cortadas previamente y aumentar salarios como lo establece una del 2025.
The silent majority: How astrocytes shape the brain across scales
Melissa Cooper talks to Mac Shine about her new work that reveals how these glial cells—long dismissed as the brain’s housekeepers—wire together in precise, long-range networks that remodel in response to experience.
The silent majority: How astrocytes shape the brain across scales
Melissa Cooper talks to Mac Shine about her new work that reveals how these glial cells—long dismissed as the brain’s housekeepers—wire together in precise, long-range networks that remodel in response to experience.