Prefrontal cortex
Recent articles
Newfound gene network controls long-range connections between emotional, cognitive brain areas
The finding could help unravel gene regulatory networks and explain how genetic and environmental factors interact in neurodevelopmental conditions.
Newfound gene network controls long-range connections between emotional, cognitive brain areas
The finding could help unravel gene regulatory networks and explain how genetic and environmental factors interact in neurodevelopmental conditions.
Neurons’ spikes may convey their whereabouts
The time lag between spurts of activity holds anatomical information, according to a preprint.
Neurons’ spikes may convey their whereabouts
The time lag between spurts of activity holds anatomical information, according to a preprint.
Synaptic anomalies in autistic people support imbalance hypothesis
Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.
Synaptic anomalies in autistic people support imbalance hypothesis
Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.
Preprint questions validity of postmortem brain studies
But the alternatives, including living-brain biopsies, raise logistical and ethical questions, experts say.
Preprint questions validity of postmortem brain studies
But the alternatives, including living-brain biopsies, raise logistical and ethical questions, experts say.
People’s perceptions of ‘social’ animations don’t always square with researchers’ labels
The finding calls into question differences between autistic and non-autistic people on a decades-old theory-of-mind test involving interacting geometric shapes.
People’s perceptions of ‘social’ animations don’t always square with researchers’ labels
The finding calls into question differences between autistic and non-autistic people on a decades-old theory-of-mind test involving interacting geometric shapes.
Neurons struggle to spike without fragile X gene
FMR1 loss impairs sodium channels, hindering mouse neurons from generating the electrical signals needed to transmit information.
Neurons struggle to spike without fragile X gene
FMR1 loss impairs sodium channels, hindering mouse neurons from generating the electrical signals needed to transmit information.
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
Autism-linked mutation disrupts brain circuit to change social behavior
Therapies that target the circuit could boost social activity, new findings suggest.
Autism-linked mutation disrupts brain circuit to change social behavior
Therapies that target the circuit could boost social activity, new findings suggest.
Histone-modifying drug improves autism-like behaviors in mice
The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.
Histone-modifying drug improves autism-like behaviors in mice
The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.
Brain’s sensory switchboard has complex connections to autism
An atypical thalamus may underlie not only sensory issues in autism but also difficulties with social skills, attention and memory.
Brain’s sensory switchboard has complex connections to autism
An atypical thalamus may underlie not only sensory issues in autism but also difficulties with social skills, attention and memory.
Explore more from The Transmitter
Targeting NMDA receptor subunit reverses fragile X traits in mice
The subunit acts as a “volume control” on signaling that shapes the density of dendritic spines, the new work suggests.
Targeting NMDA receptor subunit reverses fragile X traits in mice
The subunit acts as a “volume control” on signaling that shapes the density of dendritic spines, the new work suggests.
Maternal infection’s link to autism may be a mirage
Family-linked factors explain most associations between maternal illness and autism, a study of 1.1 million Danish children finds.
Maternal infection’s link to autism may be a mirage
Family-linked factors explain most associations between maternal illness and autism, a study of 1.1 million Danish children finds.
2025 Brain Prize honors pair of cancer neuroscientists
Michelle Monje and Frank Winkler share the $1.4 million award for their discovery of synapses between brain cancer cells and neurons.
2025 Brain Prize honors pair of cancer neuroscientists
Michelle Monje and Frank Winkler share the $1.4 million award for their discovery of synapses between brain cancer cells and neurons.