Null and Noteworthy

Recent articles

A monthly newsletter about neuroscience research that fails to support a hypothesis or replicates a previously proposed one.

Research image of mouse visual cortex neurons.

Null and Noteworthy: Downstream brain areas read visual cortex signals en masse in mice

The finding contradicts a theory that the regions prioritize neurons that are adept at identifying specific stimuli. Plus, a response to a study that questioned immune memory in astrocytes.

By Laura Dattaro
31 July 2025 | 4 min read
Research image showing that activity in single neurons spikes when a person encodes sequential items into working memory.

Null and Noteworthy: Neurons tracking sequences don’t fire in order

Instead, neurons encode the position of sequential items in working memory based on when they fire during ongoing brain wave oscillations—a finding that challenges a long-standing theory.

By Laura Dattaro
30 June 2025 | 4 min read
Research image of EEG scans showing dopamine levels in human brains.

Null and Noteworthy: Learning theory validated 20 years later

The first published paper from the #EEGManyLabs replication project nullifies a null result that had complicated a famous reinforcement learning theory.

By Laura Dattaro
30 May 2025 | 4 min read
Memory astrocytes.

Null and Noteworthy: Reanalysis contradicts report of immune memory in astrocytes

The analysis, which has not yet been peer reviewed, attributes the finding to misidentified immune cells instead.

By Laura Dattaro
30 April 2025 | 5 min read
Illustration of a line graph emanating from a beaker.

Null and Noteworthy: Reexamining registered reports

Out of 92 preregistered studies that resulted in published papers, only 15 had fully adhered to their preregistration details, according to a new analysis.

By Laura Dattaro
28 March 2025 | 5 min read
Illustration of a line graph emanating from a beaker.

Null and Noteworthy, relaunched: Probing a schizophrenia biomarker

This edition of Null and Noteworthy—the first for The Transmitter—highlights new findings about the auditory steady-state response in people with schizophrenia that, all within one study, somehow packed in a null result and a failed replication.

By Laura Dattaro
28 February 2025 | 5 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

The true meaning of a null result

This edition of Null and Noteworthy highlights results that reveal the difficulty in drawing definitive conclusions from data, including new findings about epidurals that contradict several others and an apparent null result on sex differences that may derive from “circular logic.”

By Laura Dattaro
14 August 2023 | 4 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Prenatal exposures; Angelman trial suspension; autistic adult well-being

This month’s issue of the Null and Noteworthy newsletter breaks down some negative results involving prenatal exposures, an experimental treatment for Angelman syndrome, and the role that age at autism diagnosis plays in subsequent outcomes, and more.

By Emily Harris
17 July 2023 | 4 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Modified MRI; father findings

This month’s newsletter tackles null findings from an attempted replication of a “revolutionary” MRI approach and an analysis of family genetics.

By Emily Harris
22 June 2023 | 4 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Arbaclofen results; another oxytocin edition

New data from clinical trials of arbaclofen and oxytocin underscore the murkiness of null results. Plus, researchers seek clarity on the neurodevelopmental effects of oxytocin during childbirth.

By Laura Dattaro
17 May 2023 | 4 min read

Explore more from The Transmitter

Researcher examining butterfly in lab.

Finally, a new route for the magnetic-sense field

Researchers have dueled for years over how the magnetic sense works. New data from monarch butterflies could finally help settle the debate.

By Calli McMurray
11 September 2026 | 16 min read
Child sitting on confetti-covered ground, wearing noise-cancelling headphones.

Sensory over-responsivity tied to autism, anxiety but not other conditions

Negative reactions to sensations track with certain neurodevelopmental traits in more than 15,000 children—pointing to shared neurobiological roots.

By Diana Kwon
10 September 2026 | 5 min read

Neuromechanical models deepen our understanding of animal motor control

Thanks to recent progress in physics-based simulators and robotics, it has never been easier for neuroscientists to use neuromechanical modeling to test hypotheses about animal movement.

By Auke Ijspeert
9 September 2026 | 0 min watch