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The latest developments in neuroscience

Plaque levels differ in popular Alzheimer’s mouse model depending on which parent’s variants are passed down

5XFAD model mice that inherit two disease-related genes from their fathers have double the plaques seen in those with maternal inheritance, a new study shows.

By Shaena Montanari
4 February 2025 | 0 min watch
Research image of mouse olfactory bulbs.

Olfaction; autism-linked genes in monkeys; eye movements

Here is a roundup of autism-related news and research spotted around the web for the week of 3 February.

By Jill Adams
4 February 2025 | 1 min read
Two bats in flight in black space.

Coding bonus: Bats’ hippocampal cells log spatial, social cues

The neurons represent not only an animal’s place in space, but also the distinguishing features of its fellow bats, including their sex and social status.

By Claudia López Lloreda
30 January 2025 | 5 min read
Research image of different cell types in the neocortex.

New human brain atlas charts gene activity and chromosome accessibility, from embryo to adolescence

The resource profiles millions of single cells across the developing cortex, revealing when, where and how certain cell types emerge and illuminating possible origins of autism and other conditions.

By Saima Sidik
30 January 2025 | 5 min read
Different colored file folders.

Protocol-sharing site aims to ease administrative burden of animal research

The library of regulatory-compliant animal procedures offers experimental standards and specific language that researchers can borrow for their own legal paperwork.

By Calli McMurray
29 January 2025 | 4 min read
Research image of regional structural differences in the brains of neurodiverse people.

Cortical myelination; early vocabulary; EEG in tuberous sclerosis

Here is a roundup of autism-related news and research spotted around the web for the week of 27 January.

By Jill Adams
28 January 2025 | 2 min read
Dollar sign floating at the bottom of a test tube.

Neuroscientists fear Trump’s DEI order may tank diversity-focused grants

Programs that prioritize diversity, equity and inclusion in the field may be at risk, leaving researchers in a “holding pattern,” according to one grant recipient.

By Angie Voyles Askham, Claudia López Lloreda
24 January 2025 | 5 min read
Research image of circuits emerging from striosomes in the striatum.

Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control

The two novel pathways control dopamine release in opposing ways and may link motivation and mood to action, a new study shows.

By Claudia López Lloreda
24 January 2025 | 4 min read
Research image of cells lacking microexon 4.

Protein aggregates gum up ‘master regulator’ of autism-linked genes

The regulator, CPEB4, typically controls protein production for hundreds of autism-linked genes, but an alternative version of it found in autistic people forms irreversible clumps and malfunctions.

By Giorgia Guglielmi
23 January 2025 | 4 min read
Violet-stained neurons in a serial transverse section from an embryonic spiny dogfish, a bottom-dwelling shark.

Digitization of ‘breathtaking’ neuroanatomy slide collection offers untapped research gold mine

Thousands of histological sections of vertebrate brains—including from spiny dogfish, turtles and more—are newly available online.

By Shaena Montanari
22 January 2025 | 3 min read

Explore more from The Transmitter

Image of squirrels on a branch.

NeuroAI and the hidden complexity of agency

As we attempt to build autonomous artificial-intelligence systems, we're discovering that a capability we take for granted in animals may be much more complex than we imagined.

By Anthony Zador
5 February 2025 | 6 min read
The word Doctored spelled out on pills.

‘Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s,’ an excerpt

In his new book, published today, investigative journalist Charles Piller tells the story of the scientific misconduct that shook Alzheimer’s disease research to its core, and the neuroscientist who helped to expose it.

By Charles Piller
4 February 2025 | 9 min read
Illustrated portrait of Damien Fair.

Stimulating the brain with Damien Fair

The MacArthur Foundation “genius” discusses his return to his home state of Minnesota and why it’s important to protect the developing brain.

By Brady Huggett
3 February 2025 | 68 min listen