Neuromodulators

Recent articles

Archery target.

What should the field prioritize over the next 10 years?

Respondents pointed to a range of challenges in basic neuroscience—such as understanding naturalistic behaviors, intelligence and embodied cognition—and called for more circuit-level research, more precise brain recordings and more work in alternative models. Just as many pushed for a translational pivot.

By The Transmitter
15 November 2025 | 11 min read
Research image of serotonin and dopamine neurons manipulated simultaneously in mice.

Dopamine ‘gas pedal’ and serotonin ‘brake’ team up to accelerate learning

Mice learn fastest and most reliably when they experience an increase in dopamine paired with an inhibition of serotonin in their nucleus accumbens, a new study shows, helping to resolve long-standing questions about the neuromodulators’ relationship.

By Angie Voyles Askham
12 February 2025 | 5 min read

Explore more from The Transmitter

Illustration of two cats jumping to opposite buildings in a city.

Is confidence a second thought—or part of the first one?

In some settings, neural circuits may calculate confidence in a decision simultaneously with the choice itself. That changes the types of questions researchers should ask.

By Ariel Zylberberg
5 October 2026 | 6 min read
Illustration of a plate with a cherry in front of a computer server.

What AI can learn from hunger

To enhance AI safety, take a lesson from biological brains; a small set of wants maintains durable control over a much larger cognitive system.

By Anthony Zador
5 October 2026 | 6 min read

New projectome captures ‘complex beast’ of serotonin system in mice

The whole-brain map—the first of its kind in a vertebrate—identifies five distinct neuron groups.

By Madeline Shaw
2 October 2026 | 0 min watch