Neurogenesis

Recent articles

A research image of autism-linked genes.

Autism-linked perturbations converge on cell skeleton and RNA-binding proteins

The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.

By Giorgia Guglielmi
29 February 2024 | 4 min read
Research image of organoids in the forebrain.

Head size parts autism into two major subtypes

An imbalance in the number of excitatory neurons in early brain development may account for the difference.

By Charles Q. Choi
12 September 2023 | 4 min read
Composite research image of organoids at several stages of development.

Genetic background sways effects of autism-linked mutation

Experiments offer clues to why certain mutations are associated with autism in some people and not others.

By Charles Q. Choi
18 May 2023 | 4 min read
Research image of the blood-brain barrier.

Rare autism-linked mutation starves growing neurons of essential nutrients

The mutation prevents certain amino acids from entering neurons, causing the cells to die early in development.

By Lauren Schenkman
10 April 2023 | 5 min read
Research image of radial glial cells in a human brain organoid.

Immune molecule alters cellular makeup of human brain organoids

The changes may help explain the link between maternal infection and autism, though more research is needed.

By Charles Q. Choi
5 April 2023 | 5 min listen
Research image shows elevated expression of certain genes, shown in pink and green, along with expected gene expression, shown in blue.

Autism-linked MYT1L mutations prompt ‘identity crisis’ in budding brain cells

Both human and mouse progenitor cells with the alterations struggle to become neurons and instead express genes that are typically active only in muscle or the heart.

By Laura Dattaro
14 February 2023 | 5 min read
Research image comparing neurons that lack the ZFP462 gene to wildtype neurons.

Autism-tied gene ZNF462 keeps developing neurons on track

The gene, linked to a little-known condition called Weiss-Kruszka syndrome, prevents embryonic stem cells from deviating from their neuronal destiny.

By Laura Dattaro
1 February 2023 | 4 min read
Image of a synthetic mouse embryo.

Lab-grown ‘embryoids’ offer new window into gene-trait relationships

The developmental models have advantages over natural embryos and other synthetic models, such as organoids, but present technical and ethical challenges.

By Isabel Ruehl
26 October 2022 | 4 min read

Explore more from The Transmitter

Cara Pugliese.

Autism program chief among National Institutes of Health layoffs

The termination is one of more than 1,000 employee cuts at the U.S. agency this week.

By Rachel Zamzow
21 February 2025 | 3 min read
Illustration of columns of text with eyes peeking out from behind the central column to look at a bright blue spot.

This paper changed my Life: Bill Newsome reflects on a quadrilogy of classic visual perception studies

The 1970s papers from Goldberg and Wurtz made ambitious mechanistic studies of higher brain functions seem feasible.

By Bill Newsome
21 February 2025 | 6 min read
Interconnected lines form a world map.

Science must step away from nationally managed infrastructure

Scientific data and independence are at risk. We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political interference.

By Dan Goodman
20 February 2025 | 7 min read