Mouse models
Recent articles
PTEN problems underscore autism connection to excess brain fluid
Damaging variants in the autism-linked gene cause congenital hydrocephalus—a buildup of cerebrospinal fluid in the brain—by turbocharging a downstream signaling pathway that promotes the growth of cells, according to a new study.
PTEN problems underscore autism connection to excess brain fluid
Damaging variants in the autism-linked gene cause congenital hydrocephalus—a buildup of cerebrospinal fluid in the brain—by turbocharging a downstream signaling pathway that promotes the growth of cells, according to a new study.
Unexpected astrocyte gene flips image of brain’s ‘stalwart sentinels’
The genetic marker upends the accepted orientation of non-star-like astrocytes in the glia limitans superficialis.
Unexpected astrocyte gene flips image of brain’s ‘stalwart sentinels’
The genetic marker upends the accepted orientation of non-star-like astrocytes in the glia limitans superficialis.
Molecular changes after MECP2 loss may drive Rett syndrome traits
Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.
Molecular changes after MECP2 loss may drive Rett syndrome traits
Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.
Targeting NMDA receptor subunit reverses fragile X traits in mice
The subunit acts as a “volume control” on signaling that shapes the density of dendritic spines, the new work suggests.
Targeting NMDA receptor subunit reverses fragile X traits in mice
The subunit acts as a “volume control” on signaling that shapes the density of dendritic spines, the new work suggests.
Soft touch quells loneliness in mice
Touch modulates one of two dueling types of hypothalamic neurons that, thermostat-like, balance an animal’s drive for social interaction.
Soft touch quells loneliness in mice
Touch modulates one of two dueling types of hypothalamic neurons that, thermostat-like, balance an animal’s drive for social interaction.
X marks the spot in search for autism variants
Genetic variants on the X chromosome, including those in the gene DDX53, contribute to autism’s gender imbalance, two new studies suggest.
X marks the spot in search for autism variants
Genetic variants on the X chromosome, including those in the gene DDX53, contribute to autism’s gender imbalance, two new studies suggest.
The non-model organism “renaissance” has arrived
Meet 10 neuroscientists bringing model diversity back with the funky animals they study.
The non-model organism “renaissance” has arrived
Meet 10 neuroscientists bringing model diversity back with the funky animals they study.
Expanding set of viral tools targets almost any brain cell type
Harmless viruses that encase short noncoding DNA elements called enhancers enable cell-type-specific gene delivery across the central nervous system in rodents and primates.
Expanding set of viral tools targets almost any brain cell type
Harmless viruses that encase short noncoding DNA elements called enhancers enable cell-type-specific gene delivery across the central nervous system in rodents and primates.
Stress warps fear memories in multiple ways
Expanding the bounds of a fear memory or linking it to a neutral memory can shape a mouse’s fear response, two new studies show.
Stress warps fear memories in multiple ways
Expanding the bounds of a fear memory or linking it to a neutral memory can shape a mouse’s fear response, two new studies show.
Astrocytes star in memory storage, recall
The cells, long cast as support players in memory research, can activate or disrupt fear memories, according to a new study.
Astrocytes star in memory storage, recall
The cells, long cast as support players in memory research, can activate or disrupt fear memories, according to a new study.
Explore more from The Transmitter
Split gene therapy delivers promise in mice modeling Dravet syndrome
The new approach overcomes viral packaging limitations by delivering SCN1A piecemeal and stitching it together in target cells.
Split gene therapy delivers promise in mice modeling Dravet syndrome
The new approach overcomes viral packaging limitations by delivering SCN1A piecemeal and stitching it together in target cells.
U.S. human data repositories ‘under review’ for gender identity descriptors
Researchers associated with the repositories received an email from the U.S. National Institutes of Health in March noting that they must comply with a 20 January executive order from President Trump that recognizes only two sexes: male and female.
U.S. human data repositories ‘under review’ for gender identity descriptors
Researchers associated with the repositories received an email from the U.S. National Institutes of Health in March noting that they must comply with a 20 January executive order from President Trump that recognizes only two sexes: male and female.
Inhibitory cells work in concert to orchestrate neuronal activity in mouse brain
A cubic millimeter of brain tissue, meticulously sectioned, stained and scrutinized over the past seven years, reveals in stunning detail the role of inhibitory interneurons in brain structure and function.
Inhibitory cells work in concert to orchestrate neuronal activity in mouse brain
A cubic millimeter of brain tissue, meticulously sectioned, stained and scrutinized over the past seven years, reveals in stunning detail the role of inhibitory interneurons in brain structure and function.