Modeling
Recent articles
Bringing African ancestry into cellular neuroscience
Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.
Bringing African ancestry into cellular neuroscience
Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.
The 1,000 neuron challenge
A competition to design small, efficient neural models might provide new insight into real brains—and perhaps unite disparate modeling efforts.
The 1,000 neuron challenge
A competition to design small, efficient neural models might provide new insight into real brains—and perhaps unite disparate modeling efforts.
The Transmitter’s favorite essays of 2025
Throughout a tumultuous year in science, researchers opined on policy changes and funding uncertainty, as well as scientific trends and the impact of artificial-intelligence tools on the field.
The Transmitter’s favorite essays of 2025
Throughout a tumultuous year in science, researchers opined on policy changes and funding uncertainty, as well as scientific trends and the impact of artificial-intelligence tools on the field.
What is the future of organoid and assembloid regulation?
Four experts weigh in on how to establish ethical guardrails for research on the 3D neuron clusters as these models become ever more complex.
What is the future of organoid and assembloid regulation?
Four experts weigh in on how to establish ethical guardrails for research on the 3D neuron clusters as these models become ever more complex.
Tatiana Engel explains how to connect high-dimensional neural circuitry with low-dimensional cognitive functions
Neuroscientists have long sought to understand the relationship between structure and function in the vast connectivity and activity patterns in the brain. Engel discusses her modeling approach to discovering the hidden patterns that connect the two.
Tatiana Engel explains how to connect high-dimensional neural circuitry with low-dimensional cognitive functions
Neuroscientists have long sought to understand the relationship between structure and function in the vast connectivity and activity patterns in the brain. Engel discusses her modeling approach to discovering the hidden patterns that connect the two.
Whole-brain, bottom-up neuroscience: The time for it is now
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology and how neurons work together to generate behavior.
Whole-brain, bottom-up neuroscience: The time for it is now
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology and how neurons work together to generate behavior.
The visual system’s lingering mystery: Connecting neural activity and perception
Figuring out how the brain uses information from visual neurons may require new tools. I asked 10 neuroscientists what experimental and conceptual methods they think we’re missing.
The visual system’s lingering mystery: Connecting neural activity and perception
Figuring out how the brain uses information from visual neurons may require new tools. I asked 10 neuroscientists what experimental and conceptual methods they think we’re missing.
Meet the Autism Data Science Initiative grantees
The awarded projects plan to study gene-and-environment interactions in people, stem cells and organoids, as well as predictors of positive life outcomes in autistic youth and adults.
Meet the Autism Data Science Initiative grantees
The awarded projects plan to study gene-and-environment interactions in people, stem cells and organoids, as well as predictors of positive life outcomes in autistic youth and adults.
Worms help untangle brain structure/function mystery
The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans.
Worms help untangle brain structure/function mystery
The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans.
Breaking the jar: Why NeuroAI needs embodiment
Brain function is inexorably shaped by the body. Embracing this fact will benefit computational models of real brain function, as well as the design of artificial neural networks.
Breaking the jar: Why NeuroAI needs embodiment
Brain function is inexorably shaped by the body. Embracing this fact will benefit computational models of real brain function, as well as the design of artificial neural networks.
Explore more from The Transmitter
How artificial agents can help us understand social recognition
Neuroscience is chasing the complexity of social behavior, yet we have not answered the simplest question in the chain: How does a brain know “who is who”? Emerging multi-agent artificial intelligence may help accelerate our understanding of this fundamental computation.
How artificial agents can help us understand social recognition
Neuroscience is chasing the complexity of social behavior, yet we have not answered the simplest question in the chain: How does a brain know “who is who”? Emerging multi-agent artificial intelligence may help accelerate our understanding of this fundamental computation.
Methodological flaw may upend network mapping tool
The lesion network mapping method, used to identify disease-specific brain networks for clinical stimulation, produces a nearly identical network map for any given condition, according to a new study.
Methodological flaw may upend network mapping tool
The lesion network mapping method, used to identify disease-specific brain networks for clinical stimulation, produces a nearly identical network map for any given condition, according to a new study.
Common and rare variants shape distinct genetic architecture of autism in African Americans
Certain gene variants may have greater weight in determining autism likelihood for some populations, a new study shows.
Common and rare variants shape distinct genetic architecture of autism in African Americans
Certain gene variants may have greater weight in determining autism likelihood for some populations, a new study shows.