Microscopy

Recent articles

Detailed image of neurons in the mouse visual cortex.

Inhibitory cells work in concert to orchestrate neuronal activity in mouse brain

A cubic millimeter of brain tissue, meticulously sectioned, stained and scrutinized over the past seven years, reveals in stunning detail the role of inhibitory interneurons in brain structure and function.

By Katie Moisse
9 April 2025 | 6 min read
Astrocytes in a mouse brain.

Unexpected astrocyte gene flips image of brain’s ‘stalwart sentinels’

The genetic marker upends the accepted orientation of non-star-like astrocytes in the glia limitans superficialis.

By Lauren Schenkman
28 March 2025 | 5 min read

New tissue-clearing techniques let microscopes peer deeper into living brains

Washing mouse brain tissue with a blood protein or complex sugar can illuminate cells 550 micrometers into the cortex without compromising its normal physiology.

By Calli McMurray
18 October 2024 | 0 min watch

Octopus arm anatomy, molecular makeup revealed in new maps

The datasets provide “a very nice reference” for future functional studies.

By Calli McMurray
25 September 2024 | 1 min watch
A dense reconstruction of layer 2/3 neurons of the mouse visual cortex containing 394 neurons and 3.2 million synapses.

To develop better nervous-system visualizations, we need to think BIG

With a full mouse connectome on the horizon, neuroscience needs to overcome its legacy of minimalism and embrace the contemporary challenge of representing whole-nervous-system connectivity.

By Tyler Sloan
8 July 2024 | 8 min read
Image of neural activity in a mouse as seen through the Miniscope.

Designing an open-source microscope

Funding for the development of open-source tools is on the rise, but support for their maintenance and dissemination, both crucial for their meaningful uptake, remains a major challenge.

By Daniel Aharoni
17 June 2024 | 6 min read

Getting musical to spot patterns in whole-brain imaging data: Q&A with Elizabeth Hillman

The new technique takes advantage of humans’ “extraordinary” sensory processing abilities, Hillman says.

By Calli McMurray
21 February 2024 | 0 min watch

Robotic headgear records brain activity in moving mice

The tool could help researchers study the neurobiology of natural behaviors, scientists say.

By Holly Barker
3 August 2023 | 5 min read

Explore more from The Transmitter

Close-up of high-resolution fMRI images.

Functional MRI can do more than you think

Recent technological advances provide a range of new and different information about brain physiology. But taking full advantage of these gains depends on collaboration between engineers and neuroscientists.

By Laura Lewis
14 April 2025 | 6 min read
People help each other climb up a supersized human brain.

As federal funders desert mentorship programs for marginalized students, trainee-led initiatives fill the gap

Grassroots organizations, led by graduate students and postdoctoral researchers, are stepping up to provide neuroscience career training and guidance for students from marginalized backgrounds—and they need your support.

By Christian Cazares, Maribel Patiño
11 April 2025 | 5 min read
Research image of two mouse brain slices.

Split gene therapy delivers promise in mice modeling Dravet syndrome

The new approach overcomes viral packaging limitations by delivering SCN1A piecemeal and stitching it together in target cells.

By Holly Barker
10 April 2025 | 5 min read