Microcephaly
Recent articles
New organoid atlas unveils four neurodevelopmental signatures
The comprehensive resource details data on microcephaly, polymicrogyria, epilepsy and intellectual disability from 352 people.
New organoid atlas unveils four neurodevelopmental signatures
The comprehensive resource details data on microcephaly, polymicrogyria, epilepsy and intellectual disability from 352 people.
Brain patterning in utero may be implicated in autism, other conditions
Genes tied to several conditions are expressed in regions that control neural stem cell fate within the first few months post-conception.
Brain patterning in utero may be implicated in autism, other conditions
Genes tied to several conditions are expressed in regions that control neural stem cell fate within the first few months post-conception.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
Some social issues in DYRK1A model mice stem from faulty inhibitory circuits
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Some social issues in DYRK1A model mice stem from faulty inhibitory circuits
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Dietary changes ease traits in rare autism-linked condition
Early treatment with nutritional supplements and a high-protein diet forestalls some neurodevelopmental problems for children with BCKDK deficiency.
Dietary changes ease traits in rare autism-linked condition
Early treatment with nutritional supplements and a high-protein diet forestalls some neurodevelopmental problems for children with BCKDK deficiency.
Mice without DDX3X are slow to grow neurons
The gene helps neurons exit the cell-maturation cycle during fetal brain development, a new study shows. But male and female mice respond differently to DDX3X loss.
Mice without DDX3X are slow to grow neurons
The gene helps neurons exit the cell-maturation cycle during fetal brain development, a new study shows. But male and female mice respond differently to DDX3X loss.
Precocious neurons may stunt brain growth in rare form of autism
The first animal model of MYT1L syndrome suggests that fast-maturing neurons lead to the unusually small brains, social deficits and other traits seen in people with the condition.
Precocious neurons may stunt brain growth in rare form of autism
The first animal model of MYT1L syndrome suggests that fast-maturing neurons lead to the unusually small brains, social deficits and other traits seen in people with the condition.
Critical time window flagged for autism gene’s influence
A transplant of inhibitory neurons during the second week of life prevents social difficulties and a brain signaling imbalance in mice missing a copy of FOXG1.
Critical time window flagged for autism gene’s influence
A transplant of inhibitory neurons during the second week of life prevents social difficulties and a brain signaling imbalance in mice missing a copy of FOXG1.
Jump-starting growth signaling reverses microcephaly in autism mouse model
A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.
Jump-starting growth signaling reverses microcephaly in autism mouse model
A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.
New method probes genes’ function in brain organoids
A screening technique tests how inactivated genes affect spheres of cultured brain cells; it could shed light on autism-linked mutations.
New method probes genes’ function in brain organoids
A screening technique tests how inactivated genes affect spheres of cultured brain cells; it could shed light on autism-linked mutations.
Explore more from The Transmitter
Tom Griffiths describes how neural networks, logic and probability theory together explain cognition
In his new book, “The Laws of Thought,” Griffiths shows how these three pillars of study complement one another and together form a solid foundation to eventually explain all of our cognition, from brain to mind.
Tom Griffiths describes how neural networks, logic and probability theory together explain cognition
In his new book, “The Laws of Thought,” Griffiths shows how these three pillars of study complement one another and together form a solid foundation to eventually explain all of our cognition, from brain to mind.
This paper changed my life: Talia Lerner reflects on dopamine neuron diversity and the value of simple experiments
In a 2011 Neuron study, Stephan Lammel and his colleagues showed that dopamine neurons with different projections have different physiological properties. The work inspired Lerner to think about how to challenge widely held assumptions in the field.
This paper changed my life: Talia Lerner reflects on dopamine neuron diversity and the value of simple experiments
In a 2011 Neuron study, Stephan Lammel and his colleagues showed that dopamine neurons with different projections have different physiological properties. The work inspired Lerner to think about how to challenge widely held assumptions in the field.
Portfolio of SCN2A gene variants, and more
Here is a roundup of autism-related news and research spotted around the web for the week of 9 March.
Portfolio of SCN2A gene variants, and more
Here is a roundup of autism-related news and research spotted around the web for the week of 9 March.