Methods

Recent articles

Violet-stained neurons in a serial transverse section from an embryonic spiny dogfish, a bottom-dwelling shark.

Digitization of ‘breathtaking’ neuroanatomy slide collection offers untapped research gold mine

Thousands of histological sections of vertebrate brains—including from spiny dogfish, turtles and more—are newly available online.

By Shaena Montanari
22 January 2025 | 3 min read
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David Krakauer reflects on the foundations and future of complexity science

In his book “The Complex World,” Krakauer explores how complexity science developed, from its early roots to the four pillars that now define it—entropy, evolution, dynamics and computation.

By Paul Middlebrooks
14 January 2025 | 106 min listen
An illustration of a magnifying glass, checklists, and anonymous figures.

Spectrum 2024: Year in review

We round up our most notable autism stories of the past 12 months.

By Daisy Yuhas
23 December 2024 | 2 min read
Illustration of a shrew, sandpiper, locust, axolotl, monarch butterfly, African killifish, naked mole rat, octopus, bat and cichlid.

The non-model organism “renaissance” has arrived

Meet 10 neuroscientists bringing model diversity back with the funky animals they study.

Black-and-white image of cubes floating out of the bottom half of a human head.

Solving intelligence requires new research and funding models

Our research ecosystem isn't built to deliver the breakthroughs needed to understand intelligence at scale. We need a dedicated research institution to take up the task.

By David A. Markowitz
13 December 2024 | 6 min read
Illustration of a person holding a box that is emitting laser-like beams and projecting a large curved black surface.

Imagining the ultimate systems neuroscience paper

A growing body of papers on systems neuroscience and on giant simulations of neural circuits involves data beyond the point that anyone can reasonably understand end to end. Looking ahead, “paper-bots” could solve that problem.

By Mark Humphries
2 December 2024 | 8 min read
Illustration of a funnel taking abstract shapes in at the top and spouting an organized flow of shapes out at the bottom.

To keep or not to keep: Neurophysiology’s data dilemma

An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.

By Nima Dehghani
25 November 2024 | 5 min read

Expanding set of viral tools targets almost any brain cell type

Harmless viruses that encase short noncoding DNA elements called enhancers enable cell-type-specific gene delivery across the central nervous system in rodents and primates.

By Holly Barker
19 November 2024 | 2 min watch
Illustration of a thermostat set to 22 point 5 degrees celsius, with a silhouette of a mouse adjusting its dial.

Mouse housing temperatures can cook experimental outcomes

Neuroscientists need to take note of how thermoregulatory processes influence the brain and behavior—for the sake of reproducibility and animal welfare.

By Caitlin James, Elizabeth Repasky, Sandra Sexton
5 November 2024 | 5 min read
Research image of neuron positions over time in mouse brain recordings.

Electrical fingerprints track single neurons over several months

The new approach, called UnitMatch, improves on past methods for analyzing large electrophysiological datasets, the researchers say.

By Claudia López Lloreda
1 November 2024 | 6 min read

Explore more from The Transmitter

Research image of cells lacking microexon 4.

Protein aggregates gum up ‘master regulator’ of autism-linked genes

The regulator, CPEB4, typically controls protein production for hundreds of autism-linked genes, but an alternative version of it found in autistic people forms irreversible clumps and malfunctions.

By Giorgia Guglielmi
23 January 2025 | 4 min read
Research image of brain organoids with astroglia formation represented in green.

Personalized medicine; astroglia organoids; fast track for fragile X drug

Here is a roundup of autism-related news and research spotted around the web for the week of 20 January.

By Jill Adams
21 January 2025 | 2 min read
Illustration of clinicians, a pill bottle, a speech bubble and shadowy figures.

Neuroscientists need to do better at explaining basic mental health research

The knowledge gap between scientists, health-care professionals, policymakers and people with mental health conditions is growing, slowing the translation of basic science to new treatments. Like lawyers learning to present a case to the court, scientists should learn to educate nonscientists about their findings.

By Omar Abubaker, Karla Kaun, Eric J. Nestler
21 January 2025 | 7 min read