MECP2
Recent articles
Exon-skipping approach boosts levels of key Rett syndrome protein
Deleting a small region of the MECP2 gene partially restored function in neurons derived from people with Rett-associated variants.
Exon-skipping approach boosts levels of key Rett syndrome protein
Deleting a small region of the MECP2 gene partially restored function in neurons derived from people with Rett-associated variants.
Molecular changes after MECP2 loss may drive Rett syndrome traits
Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.
Molecular changes after MECP2 loss may drive Rett syndrome traits
Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.
Parasite-based tool delivers MECP2 and other proteins to neurons
A method that uses a common brain parasite could help replenish the proteins deficient in Rett syndrome and other conditions.
Parasite-based tool delivers MECP2 and other proteins to neurons
A method that uses a common brain parasite could help replenish the proteins deficient in Rett syndrome and other conditions.
Autism-linked genes shape touch processing through different mechanisms, at different times
Whereas some mice display hypersensitivity to touch only as adults, others respond that way from birth.
Autism-linked genes shape touch processing through different mechanisms, at different times
Whereas some mice display hypersensitivity to touch only as adults, others respond that way from birth.
On the periphery: Thinking ‘outside the brain’ offers new ideas about autism
Neuronal alterations outside the brain may help to explain a host of the condition’s characteristic traits, including sensory changes, gut problems and motor differences.
On the periphery: Thinking ‘outside the brain’ offers new ideas about autism
Neuronal alterations outside the brain may help to explain a host of the condition’s characteristic traits, including sensory changes, gut problems and motor differences.
FDA approval of trofinetide may spur further drug development for Rett
The drug, welcomed by patients, might be just the first of many.
FDA approval of trofinetide may spur further drug development for Rett
The drug, welcomed by patients, might be just the first of many.
Debut drug for Rett syndrome at edge of approval
The U.S. Food and Drug Administration plans to make an approval decision on the first-ever drug for girls and women with Rett syndrome by 12 March.
Debut drug for Rett syndrome at edge of approval
The U.S. Food and Drug Administration plans to make an approval decision on the first-ever drug for girls and women with Rett syndrome by 12 March.
Going on Trial: Orphan drugs; CBD; bumetanide
This month’s newsletter takes a close look at the orphan drug program in the United States, several cannabis-based therapies and a secondary analysis of bumetanide, among other new developments in autism-related drug trials.
Going on Trial: Orphan drugs; CBD; bumetanide
This month’s newsletter takes a close look at the orphan drug program in the United States, several cannabis-based therapies and a secondary analysis of bumetanide, among other new developments in autism-related drug trials.
Epigenome edits unmute MECP2 in Rett-like neurons
The approach removes methyl tags from the gene and shields it from other silencing factors without changing the gene itself, raising hopes for a new treatment.
Epigenome edits unmute MECP2 in Rett-like neurons
The approach removes methyl tags from the gene and shields it from other silencing factors without changing the gene itself, raising hopes for a new treatment.
RNA rewrite improves breathing, survival in Rett mice
The technique involves editing the cellular instructions to make MECP2 protein and partially restores its levels in the brainstem.
RNA rewrite improves breathing, survival in Rett mice
The technique involves editing the cellular instructions to make MECP2 protein and partially restores its levels in the brainstem.
Explore more from The Transmitter
AI can’t solve the brain without data that fit together
The brain's first foundation models exist because some areas of neuroscience did the slow work of developing and adopting standards to help integrate data. Artificial intelligence cannot do that work for us.
AI can’t solve the brain without data that fit together
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Queerying neuroscience: How legislation and institutions reframe LGBTQIA+ researchers’ careers
In honor of Pride Month, The Transmitter spoke with three researchers who surveyed hundreds of LGBTQIA+ neuroscientists to better understand how institutional support, harassment and policy intersect to shape their professional trajectories.
Queerying neuroscience: How legislation and institutions reframe LGBTQIA+ researchers’ careers
In honor of Pride Month, The Transmitter spoke with three researchers who surveyed hundreds of LGBTQIA+ neuroscientists to better understand how institutional support, harassment and policy intersect to shape their professional trajectories.
Remembering Avis H. Cohen, who bridged disciplines to decode lamprey locomotion
The founding director of the University of Maryland’s Neuroscience and Cognitive Science program brought neuroscience, math and engineering together.
Remembering Avis H. Cohen, who bridged disciplines to decode lamprey locomotion
The founding director of the University of Maryland’s Neuroscience and Cognitive Science program brought neuroscience, math and engineering together.