Macrocephaly

Recent articles

Research image of two fluorescent-stained organoids.

CRISPR gives autism-linked genes a boost, rescues functioning

A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.

By Giorgia Guglielmi
23 May 2024 | 5 min read
Research image of organoids in the forebrain.

Head size parts autism into two major subtypes

An imbalance in the number of excitatory neurons in early brain development may account for the difference.

By Charles Q. Choi
12 September 2023 | 4 min read
Composite research image of organoids at several stages of development.

Genetic background sways effects of autism-linked mutation

Experiments offer clues to why certain mutations are associated with autism in some people and not others.

By Charles Q. Choi
18 May 2023 | 4 min read
A white mouse, brown mouse and black mouse stand inside a wooden circle against a blue background.

CHD8 mutation in 33 mouse strains yields range of traits

The findings put genetic background forward to help explain autism’s heterogeneity.

By Peter Hess
3 February 2023 | 5 min read
Geometric black-and-white brain model over a grid.

Excess of ‘don’t eat me’ cell signals may drive brain enlargement in autism

The signal, called CD47, is disrupted in autistic people who have a larger-than-average head.

By Peter Hess
22 November 2022 | 4 min read
Three scans of zebrafish brains.

Zebrafish point to new gene involved in brain overgrowth, autism

The gene, YTHDF2, has not previously been linked to autism.

By Katharine Gammon
1 November 2022 | 3 min read
A woman in a lab coat types at a computer.

New diagnostic code for PTEN syndrome may spur research

The code may help scientists identify people with the autism-linked condition and recruit them into clinical trials.

By Nicholette Zeliadt
3 October 2022 | 4 min read

Different forms of autism have opposite problems with brain precursor cells

The cells’ altered proliferation rates hint at ways to diagnose and potentially treat autism earlier.

By Charles Q. Choi
10 June 2022 | 4 min read
Three views of zebrafish.

Novel gene linked to brain size in autistic people

The gene, YTHDF2, may be one of several that contribute to an autism subtype marked by an unusually big brain.

By Laura Dattaro
16 May 2022 | 2 min read
organoids in early stages of development.

Organoids show how mutations in top autism gene may lead to brain overgrowth in people

The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.

By Peter Hess
19 April 2022 | 3 min read

Explore more from The Transmitter

Piggy bank with blindfold.

Future remains uncertain for U.S. federal funding of behavioral, cognitive science

The National Science Foundation did not include any solicitations for its social, behavioral and economic sciences directorate in its latest round of funding opportunities, nor replace any outgoing program officers—which poses an existential threat for the program, says nonprofit executive Wendy Naus.

By Calli McMurray
26 August 2026 | 5 min read

How energy determines where proteins are produced in neurons

Tatjana Tchumatchenko explains how mathematical modeling elucidates whether ion-channel proteins are produced locally in the soma or in the dendrites.

By Gaute Einevoll
26 August 2026 | 104 min listen
A brown mouse between a red cube and blue cylinder looks curiously at the top of the cylinder, standing on hind legs.

Wouldn’t you like to know? A mouse would

Mice seek information for curiosity’s sake—and their desire for knowledge versus a payout is represented distinctly in the brain, new findings suggest.

By Sarah Thau
26 August 2026 | 5 min read