Ion channels

Recent articles

Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.

By Olivia Gieger
4 September 2024 | 6 min read
Photograph of Theanne Griffith sitting at a table with her hands interlocked over a stack of books, with one that she has published at the very top.

Crafting tales of science with Theanne Griffith

A lifelong passion for writing helped the neuroscientist land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes.

By Angie Voyles Askham
26 August 2024 | 8 min read
Research image of two fluorescent-stained organoids.

CRISPR gives autism-linked genes a boost, rescues functioning

A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.

By Giorgia Guglielmi
23 May 2024 | 5 min read
Research image of microglia in mice.

Microglial overreaction to atypical neurons may drive autism

In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.

By Holly Barker
21 March 2024 | 5 min read
Black-and-white photograph of William Catterall in a lab.

The legacy of William Catterall, ‘father of ion channels’

Catterall, who characterized the structure, function and regulation of sodium and calcium channels crucial for neuronal excitability, died last month at the age of 77.

By Calli McMurray
12 March 2024 | 7 min read
A research image of neuronal dendrites in mice.

Top autism-linked genes join forces to shape synaptic plasticity

The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.

By Holly Barker
29 January 2024 | 5 min read
Figure shows cultured human kidney cells and cultured rat cortical neurons responding to light exposure.

Unconventional optogenetics technique spurs long-lasting changes in neuronal activity

Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.

By Peter Hess
9 January 2023 | 4 min read
Laura Cancedda in Iama's lab.

Building a better drug

Iama Therapeutics is hoping a new class of molecule will prove successful against an old target in autism.

By Alla Katsnelson
6 October 2022 | 12 min read

Mini biopsies point to source of lethal seizures in model mice

Interneurons that fail to propagate electrical signals in mice that model Dravet syndrome may cause the animals, like people with the autism-linked condition, to die suddenly.

By Angie Voyles Askham
26 April 2022 | 5 min read
Micrograph showing missing sodium ion channels in cerebral cortex of mice with two mutated copies of SCN2A gene.

Model mice hint at sodium channel gene’s contribution to autism

Altered electrical activity in the neurons of mice with a mutated copy of SCN2A may explain the animals’ autism-like social behaviors.

By Peter Hess
27 August 2021 | 4 min read

Explore more from The Transmitter

Research image of fMRI scans showing decision-making across individuals.

During decision-making, brain shows multiple distinct subtypes of activity

Person-to-person variability in brain activity might represent meaningful differences in cognitive processes, rather than random noise.

By Claudia López Lloreda
18 April 2025 | 5 min read
Tic-tac-toe board with pills representing x’s and o’s.

Basic pain research ‘is not working’: Q&A with Steven Prescott and Stéphanie Ratté

Prescott and Ratté critique the clinical relevance of preclinical studies in the field and highlight areas for improvement.

By Sydney Wyatt
18 April 2025 | 7 min read
National Institutes of Health building cleaved in two.

Proposed NIH budget cut threatens ‘massive destruction of American science’

A leaked draft of a Trump administration proposal includes an approximately 40 percent cut to the National Institutes of Health’s budget and a major reorganization of its 27 institutes and centers.

By Angie Voyles Askham
17 April 2025 | 3 min read