Interactome

Recent articles

Research image of convergent interactions.

Autism-linked variants rewire protein networks

The myriad proteins tied to autism cluster in previously unrecognized ways that can be disrupted by specific variants in the proteins.

By Claudia López Lloreda
27 August 2026 | 5 min read

Fishing for protein partners nets clues to autism

Connections between 13 autism-linked proteins and their binding partners in excitatory neurons implicate a new molecular pathway.

By Holly Barker
6 February 2023 | 5 min read
Markov cluster showing protein interactions in mice.

Protein atlas doubles number of known interactions in mice

Thousands of protein-protein interactions mapped in mice reveal how these networks shift across seven kinds of tissue.

By Niko McCarty
26 August 2021 | 4 min read

Autism-linked protein screen reveals hundreds of new interactions

Researchers have uncovered more than 1,200 new protein-protein interactions involving proteins coded for by autism-linked genes.

By Grace Huckins
14 May 2021 | 3 min read
Two doctors look at a brain scan with a 'fingerprint' pattern over the grey matter area.

Unique brain ‘fingerprints’ may narrow search for autism subtypes

Grouping people with autism based on their unique brain-activity ‘fingerprints’ may help to identify subtypes of the condition.

By Damien Fair, Oscar Miranda Dominguez
10 July 2018 | 5 min read

New health handbook; evidence imbalance; social motivation and more

The latest manual of international disease codes is out, a franchise claims to have an autism cure, and two reports diverge on the validity of the social-motivation hypothesis.

By Emily Willingham
22 June 2018 | 4 min read
scientific illustration of protein mutations

Web-based tools reveal mutations’ effects on proteins

Two new online resources help researchers predict how mutations alter protein structure.

By Maris Fessenden
27 April 2018 | 2 min read

Tangled web of proteins holds clues to autism’s complexity

Understanding how mutations in genes linked to autism perturb the different versions of proteins the genes form could reveal new targets for treatments.

By Lilia Iakoucheva
28 February 2017 | 5 min read

Online atlas reveals huge array of protein connections

A new web-based tool charts the myriad contacts among human proteins.

By Maris Fessenden
13 January 2017 | 2 min read
Spectrum from The Transmitter.

Questions for Richard Tsien: Taking apart autism’s machinery

Autism may stem from faulty feedback loops in the brain, like an air conditioning system gone awry.

By Ann Griswold
22 March 2016 | 6 min read

Explore more from The Transmitter

New projectome captures ‘complex beast’ of serotonin system in mice

The whole-brain map—the first of its kind in a vertebrate—identifies five distinct neuron groups.

By Madeline Shaw
2 October 2026 | 0 min watch
Research image showing a grid of MRI images.

Silent, motion-resistant fMRI expands scans in behaving mice

The method, called SORDINO, captures brain images in animals while they move and interact.

By Diana Kwon
2 October 2026 | 5 min read
Illustration of DNA with genetic code.

Autism-linked variants converge on two molecular patterns in mouse brains

Gene activity across 17 autism mouse models occurs in either of two opposing transcriptomic states, supporting the idea that diverse genetic changes may converge on a few recurring biological patterns.

By Giorgia Guglielmi
1 October 2026 | 4 min read