Gene expression
Recent articles
Brain’s blue spot possesses unexpected structure-function ties
The spatial arrangement of neurons in the locus coeruleus of mice corresponds with the cells’ targets across the brain, according to a new study.
Brain’s blue spot possesses unexpected structure-function ties
The spatial arrangement of neurons in the locus coeruleus of mice corresponds with the cells’ targets across the brain, according to a new study.
Gene activity in human cortex shows striking sex differences
The results mark a “dramatic shift” in how neuroscientists think about sex differences, and they may help explain sex biases in certain neurodegenerative and neurodevelopmental conditions.
Gene activity in human cortex shows striking sex differences
The results mark a “dramatic shift” in how neuroscientists think about sex differences, and they may help explain sex biases in certain neurodegenerative and neurodevelopmental conditions.
New study questions role of persistent gene activity in memory maintenance
An experiment in sea slugs suggests transcriptional changes might fade after 24 hours.
New study questions role of persistent gene activity in memory maintenance
An experiment in sea slugs suggests transcriptional changes might fade after 24 hours.
Exon-skipping approach boosts levels of key Rett syndrome protein
Deleting a small region of the MECP2 gene partially restored function in neurons derived from people with Rett-associated variants.
Exon-skipping approach boosts levels of key Rett syndrome protein
Deleting a small region of the MECP2 gene partially restored function in neurons derived from people with Rett-associated variants.
Organoid study reveals shared brain pathways across autism-linked variants
The genetic variants initially affect brain development in unique ways, but over time they converge on common molecular pathways.
Organoid study reveals shared brain pathways across autism-linked variants
The genetic variants initially affect brain development in unique ways, but over time they converge on common molecular pathways.
Constellation of studies charts brain development, offers ‘dramatic revision’
The atlases could pinpoint pathways that determine the fate of cells linked to neurodevelopmental conditions.
Constellation of studies charts brain development, offers ‘dramatic revision’
The atlases could pinpoint pathways that determine the fate of cells linked to neurodevelopmental conditions.
Gene-activity map of developing brain reveals new clues about autism’s sex bias
Boys and girls may be vulnerable to different genetic changes, which could help explain why the condition is more common in boys despite linked variants appearing more often in girls.
Gene-activity map of developing brain reveals new clues about autism’s sex bias
Boys and girls may be vulnerable to different genetic changes, which could help explain why the condition is more common in boys despite linked variants appearing more often in girls.
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Cell ‘antennae’ link autism, congenital heart disease
Variants in genes tied to both conditions derail the formation of cilia, the tiny hair-like structure found on almost every cell in the body, a new study finds.
Cell ‘antennae’ link autism, congenital heart disease
Variants in genes tied to both conditions derail the formation of cilia, the tiny hair-like structure found on almost every cell in the body, a new study finds.
Four autism subtypes map onto distinct genes, traits
An analysis of more than 5,000 autistic children and their siblings underscores the idea that autism can be understood as multiple conditions with distinct trajectories.
Four autism subtypes map onto distinct genes, traits
An analysis of more than 5,000 autistic children and their siblings underscores the idea that autism can be understood as multiple conditions with distinct trajectories.
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Supported by a $40 million NIH grant, Yale brain shuttle technology raises questions
Yale University claims its STEP platform might be able to deliver gene-editing tools into the brain via multiple routes. Researchers are eager to see more.
Supported by a $40 million NIH grant, Yale brain shuttle technology raises questions
Yale University claims its STEP platform might be able to deliver gene-editing tools into the brain via multiple routes. Researchers are eager to see more.
What counts as a ‘naturalistic’ behavior?
Nedah Nemati explains how neuroscience methods and the lived experience of the scientists themselves shape how we define the behaviors we seek to explain.
What counts as a ‘naturalistic’ behavior?
Nedah Nemati explains how neuroscience methods and the lived experience of the scientists themselves shape how we define the behaviors we seek to explain.
Allen Institute sets sights on treatments for five brain diseases
The Brain Health Accelerator program aims to harness single-cell transcriptomics and cell-type-specific genetic tools to develop treatments for Alzheimer’s, Huntington’s and Parkinson’s diseases, Lewy body dementia and ALS.
Allen Institute sets sights on treatments for five brain diseases
The Brain Health Accelerator program aims to harness single-cell transcriptomics and cell-type-specific genetic tools to develop treatments for Alzheimer’s, Huntington’s and Parkinson’s diseases, Lewy body dementia and ALS.