Gene expression
Recent articles
Unexpected astrocyte gene flips image of brain’s ‘stalwart sentinels’
The genetic marker upends the accepted orientation of non-star-like astrocytes in the glia limitans superficialis.
Unexpected astrocyte gene flips image of brain’s ‘stalwart sentinels’
The genetic marker upends the accepted orientation of non-star-like astrocytes in the glia limitans superficialis.
New tool may help untangle downstream effects of autism-linked genes
The statistical approach helps scientists better control for both measured and unmeasured confounders in gene-expression data, revealing causal relationships between autism-linked genetic variants and downstream cellular effects, such as impaired neuron development.
New tool may help untangle downstream effects of autism-linked genes
The statistical approach helps scientists better control for both measured and unmeasured confounders in gene-expression data, revealing causal relationships between autism-linked genetic variants and downstream cellular effects, such as impaired neuron development.
Molecular changes after MECP2 loss may drive Rett syndrome traits
Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.
Molecular changes after MECP2 loss may drive Rett syndrome traits
Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.
Sequencing study spotlights tight web of genes tied to autism
The findings, shared in a preprint, help to illuminate how a large and heterogeneous group of genes could be involved in autism.
Sequencing study spotlights tight web of genes tied to autism
The findings, shared in a preprint, help to illuminate how a large and heterogeneous group of genes could be involved in autism.
Cell ‘fingerprints’ identify distinct cortical networks
These networks align with different assemblages of cells, a finding that could reveal how cellular diversity influences brain function, according to a new study.
Cell ‘fingerprints’ identify distinct cortical networks
These networks align with different assemblages of cells, a finding that could reveal how cellular diversity influences brain function, according to a new study.
Protein aggregates gum up ‘master regulator’ of autism-linked genes
The regulator, CPEB4, typically controls protein production for hundreds of autism-linked genes, but an alternative version of it found in autistic people forms irreversible clumps and malfunctions.
Protein aggregates gum up ‘master regulator’ of autism-linked genes
The regulator, CPEB4, typically controls protein production for hundreds of autism-linked genes, but an alternative version of it found in autistic people forms irreversible clumps and malfunctions.
Huntington’s disease gene variants past a certain size poison select cells
The findings—providing “the next step in the whole pathway”—help explain the disease’s late onset and offer hope that it has an extended therapeutic window.
Huntington’s disease gene variants past a certain size poison select cells
The findings—providing “the next step in the whole pathway”—help explain the disease’s late onset and offer hope that it has an extended therapeutic window.
Brain gene expression syncs between bonded prairie voles
The overlapping activity in the animals’ nucleus accumbens may underpin pair bonding, a new preprint suggests.
Brain gene expression syncs between bonded prairie voles
The overlapping activity in the animals’ nucleus accumbens may underpin pair bonding, a new preprint suggests.
START method assembles brain’s wiring diagram by cell type
The new technique mapped the interactions of about 50 kinds of inhibitory neurons in the mouse visual cortex in finer detail than previous approaches.
START method assembles brain’s wiring diagram by cell type
The new technique mapped the interactions of about 50 kinds of inhibitory neurons in the mouse visual cortex in finer detail than previous approaches.
Untangling biological threads from autism’s phenotypic patchwork reveals four core subtypes
People belonging to the same subtype share genetic variants, behaviors and often co-occurring diagnoses, according to a new preprint.
Untangling biological threads from autism’s phenotypic patchwork reveals four core subtypes
People belonging to the same subtype share genetic variants, behaviors and often co-occurring diagnoses, according to a new preprint.
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Who funds your basic neuroscience research? Help The Transmitter compile a list of funding sources
We want to hear from you about the sources of funding for your research.
Who funds your basic neuroscience research? Help The Transmitter compile a list of funding sources
We want to hear from you about the sources of funding for your research.
The future of neuroscience research at U.S. minority-serving institutions is in danger
Cuts to federally funded programs present an existential crisis for the University of Puerto Rico’s rich neuroscience community and for research at minority-serving institutions everywhere.
The future of neuroscience research at U.S. minority-serving institutions is in danger
Cuts to federally funded programs present an existential crisis for the University of Puerto Rico’s rich neuroscience community and for research at minority-serving institutions everywhere.
Null and Noteworthy: Reexamining registered reports
Out of 92 preregistered studies that resulted in published papers, only 15 had fully adhered to their preregistration details, according to a new analysis.
Null and Noteworthy: Reexamining registered reports
Out of 92 preregistered studies that resulted in published papers, only 15 had fully adhered to their preregistration details, according to a new analysis.