Dopamine

Recent articles

By clicking to watch this video, you agree to our privacy policy.

Vijay Namboodiri and Ali Mohebi on the evolving story of dopamine’s role in cognitive function

Researchers discuss the classic stories of dopamine’s role in learning, ongoing work linking it to a wide variety of cognitive functions, and recent research suggesting that dopamine may help us "look back" to discover the causes of events in the world.

By Paul Middlebrooks
27 September 2024 | 97 min listen
Illustration of cranes attempting to assemble a structure out of very small black squares.

Reconstructing dopamine’s link to reward

The field is grappling with whether to modify the long-standing theory of reward prediction error—or abandon it entirely.

By Angie Voyles Askham
13 September 2024 | 20 min listen
Illustration of cranes attempting to assemble a structure out of very small black squares.

Dopamine and the need for alternative theories

Some experimental findings are inconsistent with the dominant model of reward prediction error, highlighting the need for alternative testable and falsifiable models for dopamine function.

By Vijay Mohan K. Namboodiri
13 September 2024 | 7 min read
Illustration of several structures constructed out of small black squares, with scaffolding on some of the structures.

Does a new theory of dopamine replace the classic model?

My answer would be no, but the model poses challenges that will sharpen our understanding of dopamine and learning.

By Naoshige Uchida
13 September 2024 | 8 min read
Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.

By Olivia Gieger
4 September 2024 | 6 min read
A diagram of green neurnons

Cocaine, morphine commandeer neurons normally activated by food, water in mice

Confirming a long-held hypothesis, repeated exposure to the drugs alters neurons in the nucleus accumbens, the brain’s reward center, and curbs an animal’s urge for sustenance.

By Lauren Schenkman
8 May 2024 | 5 min read
Research images of the human motor cortex

What happens when a histopathologist teams up with computational modelers?

Answers emerge in my chat with Nicola Palomero-Gallagher, a rare example of someone who connects the brain’s microscopic constituents and macroscopic features.

By Mac Shine
11 December 2023 | 7 min read

Mouse study links dopamine in cerebellum to social behavior

The signaling molecule’s social role in the ‘little brain’ involves Purkinje neurons in the Crus I and Crus II regions, a new study reveals.

By Sarah DeWeerdt
6 July 2022 | 5 min read

Poor sleep shifts social circuit in mice

Even temporary bouts of too little non-REM sleep can lead to long-term changes in how the animals respond to certain social situations, new research suggests.

By Angie Voyles Askham
20 June 2022 | 5 min read
Brain scan showing communication from amygdala to hypothalamus about social reward.

Brain circuit makes social interactions rewarding, may be altered in autism

Blocking connections between the amygdala and hypothalamus prevents mice from finding social interactions as rewarding as they would otherwise.

By Angie Voyles Askham
30 April 2021 | 4 min read

Explore more from The Transmitter

By clicking to watch this video, you agree to our privacy policy.

Rajesh Rao reflects on predictive brains, neural interfaces and the future of human intelligence

Twenty-five years ago, Rajesh Rao proposed a seminal theory of how brains could implement predictive coding for perception. His modern version zeroes in on actions.

By Paul Middlebrooks
18 December 2024 | 97 min listen
Portrait of Yves Fregnac

In memoriam: Yves Frégnac, influential and visionary French neuroscientist

Frégnac, who died on 18 October at the age of 73, built his career by meeting neuroscience’s complexity straight on.

By Bahar Gholipour
18 December 2024 | 9 min read
Illustration shows a solitary figure moving through a green and blue field of dots moving at different rates.

Explaining ‘the largest unexplained number in brain science’: Q&A with Markus Meister and Jieyu Zheng

The human brain takes in sensory information roughly 100 million times faster than it can respond. Neuroscientists need to explore this perceptual paradox to better understand the limits of the brain, Meister and Zheng say.

By Claudia López Lloreda
17 December 2024 | 8 min read