Depression

Recent articles

Research image of mouse brain slices.

Newfound gene network controls long-range connections between emotional, cognitive brain areas

The finding could help unravel gene regulatory networks and explain how genetic and environmental factors interact in neurodevelopmental conditions.

By Charles Q. Choi
14 November 2024 | 4 min read
A younger looking set of hands holds an older looking set of hands.

New catalog charts familial ties from autism to 90 other conditions

The research tool reveals associations stretching across three generations.

By Charles Q. Choi
17 October 2024 | 4 min read
Bret Rutherford.

Former Columbia University psychiatrist committed research misconduct, says federal watchdog

Bret Rutherford, whose research was halted following a suicide in a clinical trial, falsely reported participant eligibility, according to the U.S. Office of Research Integrity.

By Brendan Borrell, Ellie Kincaid
8 October 2024 | 3 min read
Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.

By Olivia Gieger
4 September 2024 | 6 min read
Illustration of a sparkly brain.

What, if anything, makes mood fundamentally different from memory?

To better understand mood disorders—and to develop more effective treatments—should we target the brain, the mind, the environment or all three?

By Nicole Rust
8 April 2024 | 8 min read
Image of a red rectangle against a gray background.

FDA describes ‘objectionable conditions’ at New York State Psychiatric Institute

The facility’s institutional review board failed to report a 2021 incident and “serious and ongoing noncompliance” by a principal investigator, according to a letter released by the federal agency this week.

By Brendan Borrell
2 April 2024 | 6 min listen
Research image of microglia in rats.

Temperament is innate but hackable, animal studies suggest

Emotional reactivity and vulnerability to stress are largely inherited in rodents — but can be modified in early life by targeting inflammation-related cells or even just adjusting an animal’s environment.

By Holly Barker
23 January 2024 | 8 min read
Photograph of a doctor and nurse checking a patient’s temperature and taking notes.

Co-occurring conditions in autistic teens increase with age

The most prevalent conditions include obesity, neurological disorders, anxiety and attention-deficit/hyperactivity disorder.

By Calli McMurray
8 August 2023 | 1 min read

Exclusive: Shake-up at top psychiatric institute following suicide in clinical trial

The New York State Psychiatric Institute in New York City is undergoing an audit and a change in leadership following a suicide that occurred during one of its clinical trials.

By Brendan Borrell
31 July 2023 | 6 min listen
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Prenatal exposures; Angelman trial suspension; autistic adult well-being

This month’s issue of the Null and Noteworthy newsletter breaks down some negative results involving prenatal exposures, an experimental treatment for Angelman syndrome, and the role that age at autism diagnosis plays in subsequent outcomes, and more.

By Emily Harris
17 July 2023 | 4 min read

Explore more from The Transmitter

Illustration of the outlines of several different animals—including a fish, an insect and a rabbit—each filled in with a different color and overlaid with abstract patterns, lines and shapes.

Premature declarations on animal consciousness hinder progress

Overstating the evidence in support of animal consciousness could impede efforts to develop more accurate ways of assessing it.

By Hakwan Lau
18 November 2024 | 5 min read
Research image of a portion of mouse brain.

Stress warps fear memories in multiple ways

Expanding the bounds of a fear memory or linking it to a neutral memory can shape a mouse’s fear response, two new studies show.

By Claudia López Lloreda
15 November 2024 | 5 min read
Illustration of overlapping silhouettes of two faces in profile facing a matrix of dots of various colors and sizes.

How to be a multidisciplinary neuroscientist

Neuroscience subfields are often siloed. Embracing an integrative approach during training can help change that.

By Austin Coley
15 November 2024 | 5 min read