Cortex

Recent articles

Headshots of Karl Deisseroth, Peter Hegemann and Georg Nagel.

How Nobel Prize-winning optogenetics has revolutionized neuroscience

The technique has enabled neuroscientists to target brain circuits and cells with unprecedented specificity, transforming the study of memory, interoception, brain disorders and reward, among other domains.

Research diagram of task-aligned activity rasters.

Cerebellar neurons reorient brain activity to differentiate similar behaviors

The findings provide a new perspective on how granule cells help to generalize learning across tasks.

By Holly Barker
29 September 2026 | 4 min read
Mouse cortical organoid.

Hasty stem cells highlight potential limitation with cortical organoids

The models recapitulate many key developmental processes, but some radial glial cells in mouse organoids make neurons earlier than they should.

By Giorgia Guglielmi
22 September 2026 | 4 min read
Nerve fibers from the human graft in mouse brain.

Human brain organoids flourish in emptied mouse cortex

The chimeric mice could help untangle the biology of human brain development or conditions such as autism.

By Brianna Abbott
16 September 2026 | 6 min read
Neuronal genes SATB2 and MEF2C.

Nuclear location helps control gene activity during brain development

A study of developing human brain tissue suggests that genes switch on more strongly when they move from the nucleus’s edge toward structures that contain proteins involved in making and processing RNA.

By Giorgia Guglielmi
20 August 2026 | 5 min read

Alison Barth discovers how different neuron types contribute to cortical function

Barth uses learning tasks in mice as a tool to drive synaptic plasticity in the sensory cortex, hoping to unlock more general principles of how the cortex works.

By Paul Middlebrooks
5 August 2026 | 1 min read
Research image of the association cortex.

Cortical territories compete in developmental space race

Sensory and association regions are established through a reciprocal process, according to a new model of cortical development.

By Holly Barker
30 July 2026 | 5 min read
Brain scans showing sex-based activation differences.

Brain’s sex differences are subtle and contradictory, large MRI study finds

Sex-based behavioral differences do not match with variations in brain activation or structure in a study of almost 1,000 people.

By Lauren Schenkman
8 July 2026 | 5 min read
Research image of cursor movement from high gamma activity.

Recording warning: Common brain signal may be misunderstood

High gamma activity in electrophysiologic recordings reflects widespread neural activity, not merely local firing, as previously thought.

By Claudia López Lloreda
30 June 2026 | 5 min read

Cortical area remixes macaques’ knowledge blocks to solve new problems

When monkeys draw complex shapes, their neural activity reflects patterns of activation elicited by drawing simpler, component shapes.

By Lauren Schenkman
19 June 2026 | 0 min watch

Explore more from The Transmitter

Illustration of two cats jumping to opposite buildings in a city.

Is confidence a second thought—or part of the first one?

In some settings, neural circuits may calculate confidence in a decision simultaneously with the choice itself. That changes the types of questions researchers should ask.

By Ariel Zylberberg
5 October 2026 | 6 min read
Illustration of a plate with a cherry in front of a computer server.

What AI can learn from hunger

To enhance AI safety, take a lesson from biological brains; a small set of wants maintains durable control over a much larger cognitive system.

By Anthony Zador
5 October 2026 | 6 min read

New projectome captures ‘complex beast’ of serotonin system in mice

The whole-brain map—the first of its kind in a vertebrate—identifies five distinct neuron groups.

By Madeline Shaw
2 October 2026 | 0 min watch