Computational neuroscience

Recent articles

Computer-generated illustration of a brain with a faint outline of another brain superimposed slightly above it.

Does the solution to building safe artificial intelligence lie in the brain?

Now is the time to decipher what makes the brain both flexible and dependable—and to apply those lessons to AI—before an unaligned agentic system wreaks havoc.

By Patrick Mineault
17 February 2025 | 6 min read

Dmitri Chklovskii outlines how single neurons may act as their own optimal feedback controllers

From logical gates to grandmother cells, neuroscientists have employed many metaphors to explain single neuron function. Chklovskii makes the case that neurons are actually trying to control how their outputs affect the rest of the brain.

By Paul Middlebrooks
12 February 2025 | 99 min listen
A figure walks a narrow path in a canyon.

Static pay, shrinking prospects fuel neuroscience postdoc decline

Postdoctoral researchers sponsored by the National Institutes of Health now toil longer than ever before, for less money. They are responding accordingly.

By Katie Moisse
31 January 2025 | 20 min read
Multicolored illustration of a human brain as seen from the top down.

Most neurons in mouse cortex defy functional categories

The majority of cells in the cerebral cortex are unspecialized, according to an unpublished analysis—and scientists need to take care in naming neurons, the researchers warn.

By Holly Barker
7 January 2025 | 5 min read
Illustration of lines of text being distorted by red orbs.

This paper changed my life: ‘A massively parallel architecture for a self-organizing neural pattern recognition machine,’ by Carpenter and Grossberg

This paper taught me that we can use mathematical modeling to understand how neural networks are organized—and led me to a doctoral program in the department led by its authors.

By Luiz Pessoa
6 January 2025 | 3 min read

Eli Sennesh talks about bridging predictive coding and NeuroAI

Predictive coding is an enticing theory of brain function. Building on decades of models and experimental work, Eli Sennesh proposes a biologically plausible way our brain might implement it.

By Paul Middlebrooks
3 January 2025 | 98 min listen
Illustration shows a solitary figure moving through a green and blue field of dots moving at different rates.

Explaining ‘the largest unexplained number in brain science’: Q&A with Markus Meister and Jieyu Zheng

The human brain takes in sensory information roughly 100 million times faster than it can respond. Neuroscientists need to explore this perceptual paradox to better understand the limits of the brain, Meister and Zheng say.

By Claudia López Lloreda
17 December 2024 | 8 min read
High-resolution image of interconnected brain cells highlighted in magenta and blue.

What are recurrent networks doing in the brain?

The cortex is filled with excitatory local synapses, but we know little about their role in brain function. New experimental tools, along with ideas from artificial intelligence, are poised to change that.

By Mark Histed
16 December 2024 | 5 min read
Illustration of a person holding a box that is emitting laser-like beams and projecting a large curved black surface.

Imagining the ultimate systems neuroscience paper

A growing body of papers on systems neuroscience and on giant simulations of neural circuits involves data beyond the point that anyone can reasonably understand end to end. Looking ahead, “paper-bots” could solve that problem.

By Mark Humphries
2 December 2024 | 8 min read
Illustration of a brain overlaid with circles containing flowers and circuit-like networks, among other images.

NeuroAI: A field born from the symbiosis between neuroscience, AI

As the history of this nascent discipline reveals, neuroscience has inspired advances in artificial intelligence, and AI has provided a testing ground for models in neuroscience, accelerating progress in both fields.

By Anthony Zador
11 November 2024 | 7 min listen

Explore more from The Transmitter

Cara Pugliese.

Autism program chief among National Institutes of Health layoffs

The termination is one of more than 1,000 employee cuts at the U.S. agency this week.

By Rachel Zamzow
21 February 2025 | 3 min read
Illustration of columns of text with eyes peeking out from behind the central column to look at a bright blue spot.

This paper changed my Life: Bill Newsome reflects on a quadrilogy of classic visual perception studies

The 1970s papers from Goldberg and Wurtz made ambitious mechanistic studies of higher brain functions seem feasible.

By Bill Newsome
21 February 2025 | 6 min read
Interconnected lines form a world map.

Science must step away from nationally managed infrastructure

Scientific data and independence are at risk. We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political interference.

By Dan Goodman
20 February 2025 | 7 min read