Axons

Recent articles

A research image of a mouse hippocampus

Some social issues in DYRK1A model mice stem from faulty inhibitory circuits

Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.

By Giorgia Guglielmi
11 October 2023 | 4 min read
Research image of presynapses on sensory neurons in fruit flies.

UBE3A’s link to synaptic pruning bolstered by fly study

Increasing or reducing the levels of the UBE3A gene, which is associated with autism and autism-related syndromes, results in altered patterns of synaptic pruning — a process that snips away brain cell connections.

By Giorgia Guglielmi
28 September 2023 | 5 min read

Repurposed electronics lens spies neurons across entire mouse brain

When combined with tissue-inflation methods, the microscope can image axons without the need for tissue slicing, the researchers say.

By Holly Barker
14 July 2023 | 5 min listen

Autism’s ties to the cell skeleton

Many genes related to the condition play a role in the internal scaffolding of cells, and cytoskeletal disruptions can affect neurodevelopment and behavior.

By Giorgia Guglielmi
22 June 2023 | 7 min read
A hand lifts a line graph off of a page and into the air.

Nerve regeneration paper retracted over faked data

The paper marks the second retraction for one of the co-authors.

By Brendan Borrell
24 May 2023 | 4 min read

Wiring map reveals how larval fruit fly brain converts sensory signals to movement

The map diagrams more than half a million neuronal connections in the first complete connectome of Drosophila and holds clues about which brain architectures best support learning.

By Laura Dattaro
9 March 2023 | 5 min listen
Research image showing the presence of several proteins in neurons.

Protein networks identified in autism-linked genetic deletion

The OTUD7A gene, which may account for some traits in people missing a segment of chromosome 15, appears to interact with several known autism-linked genes.

By Jef Akst
28 February 2023 | 6 min read
Lab images of cilia.

Autism and the cell’s antennae

Many autism-linked genes are somehow tied to cilia, the tiny hair-like sensors that stud a cell’s surface. But the question remains whether, and how, cilia differences contribute to the condition.

By Giorgia Guglielmi
4 January 2023 | 6 min read
lllustration of the junction between two nerve cells.

Multi-omics study captures CNTNAP2’s far-ranging effects

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

By Charles Q. Choi
8 December 2022 | 4 min read
A cross-section of the human brain and limbic system

Amygdala-linked brain areas grow differently in autism

The growth differences vary between autistic boys and girls and are most apparent among children with prominent social difficulties.

By Charles Q. Choi
13 July 2022 | 5 min read

Explore more from The Transmitter

Age-related brain changes in mice strike hypothalamus ‘hot spot’

Neuronal and non-neuronal cells throughout the brain also express genes—particularly those related to neuronal structure and immune function—differently in aged mice, according to a new atlas.

By Angie Voyles Askham
8 January 2025 | 5 min read
World map color-coded to visualize the impact of autism across the world, estimating the disability-adjusted life years by nation.

Functional connectivity; ASDQ screen; health burden of autism

Here is a roundup of autism-related news and research spotted around the web for the week of 6 January.

By Jill Adams
7 January 2025 | 2 min read
Multicolored illustration of a human brain as seen from the top down.

Most neurons in mouse cortex defy functional categories

The majority of cells in the cerebral cortex are unspecialized, according to an unpublished analysis—and scientists need to take care in naming neurons, the researchers warn.

By Holly Barker
7 January 2025 | 5 min read