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A whisper of autism: Fragile X carriers and the autism phenotype
Among people who carry the fragile X premutation, about 14 percent of boys and 5 percent of girls meet the criteria for autism, but the ‘broad autism phenotype’ may be far more common.
![Book cover conceptual illustration of chromosome superimposed with genetic tree.](https://www.thetransmitter.org/wp-content/uploads/2022/04/Carriers-844.jpg)
A whisper of autism: Fragile X carriers and the autism phenotype
Among people who carry the fragile X premutation, about 14 percent of boys and 5 percent of girls meet the criteria for autism, but the ‘broad autism phenotype’ may be far more common.
Null and Noteworthy: An ineffective therapy and an effective biomarker
In this edition, a strategy to help autistic children adapt their skills to new situations shows no benefit, but an early-life autism biomarker does.
![Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.](https://www.thetransmitter.org/wp-content/uploads/2022/04/844_Null2_01.jpg)
Null and Noteworthy: An ineffective therapy and an effective biomarker
In this edition, a strategy to help autistic children adapt their skills to new situations shows no benefit, but an early-life autism biomarker does.
Q&A with W. David Lohr: Antipsychotics, polypharmacy among autistic preschoolers
Hundreds of preschool-aged children in Kentucky began taking antipsychotic medicines in 2012, according to an analysis of Medicaid records. Lohr discusses what it will it take to get them behavioral therapies instead.
![](https://www.thetransmitter.org/wp-content/uploads/2021/09/AntipsychMed-844.jpg)
Q&A with W. David Lohr: Antipsychotics, polypharmacy among autistic preschoolers
Hundreds of preschool-aged children in Kentucky began taking antipsychotic medicines in 2012, according to an analysis of Medicaid records. Lohr discusses what it will it take to get them behavioral therapies instead.
Prenatal exposure to antipsychotic medication does not increase odds of autism, ADHD
Children born to mothers who take antipsychotic drugs during pregnancy are not more likely to have autism or attention deficit hyperactivity disorder, or to be born preterm or underweight.
![Pregnant woman holding two white pills in her hand.](https://www.thetransmitter.org/wp-content/uploads/2021/08/PrenatalAntipsychotics-844.jpg)
Prenatal exposure to antipsychotic medication does not increase odds of autism, ADHD
Children born to mothers who take antipsychotic drugs during pregnancy are not more likely to have autism or attention deficit hyperactivity disorder, or to be born preterm or underweight.
Q&A with Eric Hollander: Cannabis treatments for autism
As cannabis prohibition slowly lifts in the United States, scientists and families in the autism community are increasingly turning to the drug and its constituent compounds to ease autism-related difficulties, including seizures and irritability.
![Brain and marijuana leaves](https://www.thetransmitter.org/wp-content/uploads/2021/06/20210608HollanderCBD844.jpg)
Q&A with Eric Hollander: Cannabis treatments for autism
As cannabis prohibition slowly lifts in the United States, scientists and families in the autism community are increasingly turning to the drug and its constituent compounds to ease autism-related difficulties, including seizures and irritability.
Rewind: Spectrum’s best from 2020
Our staff picks the stories, podcasts and special reports that stood out from the rest this past year.
![researcher facing off with the coronavirus.](https://www.thetransmitter.org/wp-content/uploads/2020/12/20200617-COVIDSR-844.jpg)
Rewind: Spectrum’s best from 2020
Our staff picks the stories, podcasts and special reports that stood out from the rest this past year.
Diabetes drug delivers multiple benefits for people with fragile X syndrome
Researcher Randi Hagerman is a big proponent of metformin — a diabetes drug that she is testing in people with fragile X syndrome. In fact, Hagerman takes the drug herself as a preventive measure against cancer.
![Colorful figure with a circle shape (a pill) and an orange X in the background symbolizing Fragile X](https://www.thetransmitter.org/wp-content/uploads/2019/09/20190917-McCarthy844.jpg)
Diabetes drug delivers multiple benefits for people with fragile X syndrome
Researcher Randi Hagerman is a big proponent of metformin — a diabetes drug that she is testing in people with fragile X syndrome. In fact, Hagerman takes the drug herself as a preventive measure against cancer.
Clinicians should consider off-label treatments for autism
Clinicians need a more consistent and evidence-based approach to prescribing antipsychotics to children and adolescents with autism.
![](https://www.thetransmitter.org/wp-content/uploads/2019/05/20190507-Bonati-844.jpg)
Clinicians should consider off-label treatments for autism
Clinicians need a more consistent and evidence-based approach to prescribing antipsychotics to children and adolescents with autism.
Explore more from The Transmitter
Cell population in brainstem coordinates cough, new study shows
The work also adds to a growing body of evidence showing that mice, and their genetic toolbox, can be used to study cough.
![](https://www.thetransmitter.org/wp-content/uploads/2024/09/1200_coughingmice-1024x720.webp)
Cell population in brainstem coordinates cough, new study shows
The work also adds to a growing body of evidence showing that mice, and their genetic toolbox, can be used to study cough.
In updated U.S. autism bill, Congress calls for funding boost, expanded scope
The current Autism CARES Act sunsets in late September.
![Capitol building](https://www.thetransmitter.org/wp-content/uploads/2024/09/capitolhill-1200-1024x692.webp)
In updated U.S. autism bill, Congress calls for funding boost, expanded scope
The current Autism CARES Act sunsets in late September.
Ketamine targets lateral habenula, setting off cascade of antidepressant effects
The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.
![Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.](https://www.thetransmitter.org/wp-content/uploads/2024/09/1200-ketamine-receptor-transmitter-neuroscience-1024x683.webp)
Ketamine targets lateral habenula, setting off cascade of antidepressant effects
The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.