Animal models

Recent articles

Multiple people look together at a whiteboard in a lab.

Why practical summer courses in neuroscience matter

Among other reasons, this tradition helps researchers rekindle the unfettered joy that initially brought them to the field.

By John Tuthill
13 January 2025 | 7 min read
Research image of gene expression in cells in the third ventricle of the hypothalamus of young and aged mice.

Age-related brain changes in mice strike hypothalamus ‘hot spot’

Neuronal and non-neuronal cells throughout the brain also express genes—particularly those related to neuronal structure and immune function—differently in aged mice, according to a new atlas.

By Angie Voyles Askham
8 January 2025 | 6 min listen
Illustration of a shrew, sandpiper, locust, axolotl, monarch butterfly, African killifish, naked mole rat, octopus, bat and cichlid.

The non-model organism “renaissance” has arrived

Meet 10 neuroscientists bringing model diversity back with the funky animals they study.

Research image of brain scans.

Impaired molecular ‘chaperone’ accompanies multiple brain changes, conditions

Rare genetic variants in a protein-folding complex contribute to a spectrum of phenotypes that encompass brain malformations, intellectual disability, autism and seizures, according to a new “hallmark” study.

By Holly Barker
12 December 2024 | 5 min read
Two rhesus macaque monkeys.

Vasopressin boosts sociability in solitary monkeys

Inhaling the hormone did not increase aggression in unsociable rhesus macaques and appears to help the animals remember faces and reciprocate friendly behaviors.

By Charles Q. Choi
25 November 2024 | 5 min read
Research image of mouse cells.

Immune cell interlopers breach—and repair—brain barrier in mice

The choroid plexus, the protective network of blood vessels and epithelial cells that line the brain’s ventricles, recruits neutrophils and macrophages during inflammation, a new study shows.

By Claudia López Lloreda
20 November 2024 | 6 min listen
Illustration of the outlines of several different animals—including a fish, an insect and a rabbit—each filled in with a different color and overlaid with abstract patterns, lines and shapes.

Premature declarations on animal consciousness hinder progress

Overstating the evidence in support of animal consciousness could impede efforts to develop more accurate ways of assessing it.

By Hakwan Lau
18 November 2024 | 5 min read
Research image of a portion of mouse brain.

Stress warps fear memories in multiple ways

Expanding the bounds of a fear memory or linking it to a neutral memory can shape a mouse’s fear response, two new studies show.

By Claudia López Lloreda
15 November 2024 | 5 min read
A squirrel sleeps on the ground with its toe in its mouth.

Rousing a ‘new era’ of hibernation research

Novel applications of neuroscience tools have enabled researchers to uncover the neural controls of an extreme biological trait.

By Shaena Montanari
8 November 2024 | 9 min read
Three rhesus macaque monkeys.

Monkeys’ amygdala cells adapt to social status

The cells’ activity reflects social hierarchies and may enable flexible behavior.

By Angie Voyles Askham
6 November 2024 | 4 min read

Explore more from The Transmitter

Colorful illustration of a latticework of proteins.

Cracking the code of the extracellular matrix

Despite evidence for a role in plasticity and other crucial functions, many neuroscientists still view these proteins as “brain goop.” The field needs technical advances and a shift in scientific thinking to move beyond this outdated perspective.

By Anna Victoria Molofsky
17 January 2025 | 5 min read
A repeated DNA strand extends farther from the left side of the image with each iteration.

Huntington’s disease gene variants past a certain size poison select cells

The findings—providing “the next step in the whole pathway”—help explain the disease’s late onset and offer hope that it has an extended therapeutic window.

By Angie Voyles Askham
16 January 2025 | 6 min read
Research image highlighting different brain regions.

X marks the spot in search for autism variants

Genetic variants on the X chromosome, including those in the gene DDX53, contribute to autism’s gender imbalance, two new studies suggest.

By Holly Barker
16 January 2025 | 6 min read