Amyloid beta

Recent articles

Illustration of complex, intersecting biological structures.

Everything, everywhere, all at once: Inside the chaos of Alzheimer’s disease

To truly understand Alzheimer’s disease, we may need to take a systems approach, in which inflammation, vascular injury, impaired glucose metabolism and other factors interact in complex ways.

By Michael A. Yassa
16 June 2025 | 7 min read

Plaque levels differ in popular Alzheimer’s mouse model depending on which parent’s variants are passed down

5XFAD model mice that inherit two disease-related genes from their fathers have double the plaques seen in those with maternal inheritance, a new study shows.

By Shaena Montanari
4 February 2025 | 0 min watch
Six different neurons.

Early trajectory of Alzheimer’s tracked in single-cell brain atlases

Inflammation in glia and the loss of certain inhibitory cells may kick off a disease cascade decades before diagnosis.

By Angie Voyles Askham
23 October 2024 | 8 min read
Colored transmission electron micrograph (TEM) showing an amyloid plaque in a brain with Alzheimer’s disease.

Skeptics challenge claims of Alzheimer’s disease transmission via growth hormone

Some people who received cadaver-derived human growth hormone may not have Alzheimer’s as previously suggested, according to a new Perspective article.

By Shaena Montanari
23 August 2024 | 6 min read
Research image of green and purple mouse brain slices.

Putting a bright idea to the test

A surprising wave of findings in mice suggests that light and sound flickering at 40 hertz clears the brain of Alzheimer’s-disease-linked plaques. Several companies are hoping to prove it works in people.

By Shaena Montanari
21 August 2024 | 11 min read
Image of amyloid beta plaques.

Reviving ‘inside-out’ hypothesis of amyloid beta to explain Alzheimer’s mysteries

New research is resurfacing old ideas about where the protein forms the disease’s hallmark plaques.

By Elissa Welle
29 May 2024 | 8 min read
Picture of two Degus in a cage.

How inbreeding almost tanked an up-and-coming model of Alzheimer’s disease

But new genetic analyses and behavioral assays have made the Chilean degu a viable model again, researchers say.

By Calli McMurray
21 May 2024 | 10 min read
Photograph of Carol Jennings.

Carol Jennings, whose family’s genetics informed amyloid cascade hypothesis, dies at 70

Her advocacy work aided the discovery of a rare inherited form of early-onset Alzheimer’s disease and helped connect affected people with researchers.

By Elissa Welle
30 April 2024 | 4 min read

Explore more from The Transmitter

A computer cursor hovers over distorted data.

Neuroscientists challenge NIH’s proposed human-data access policy

The changes would restrict the sharing of human neuroimaging, transcriptomic and genetic data.

By Claudia López Lloreda
17 March 2026 | 5 min read

David Sussillo on persistence, luck and the bonds between life and work

In a Q&A about his new book, “Emergence,” Sussillo shares why he wrote it and how challenging circumstances shaped his journey into neuroscience.

By Francisco J. Rivera Rosario, David Sussillo
17 March 2026 | 9 min read
Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Leucovorin, long-read sequencing, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 16 March.

By Jill Adams
17 March 2026 | 2 min read